WebArizona State University WebOct 29, 2024 · Interestingly, pipelines that exclusively prioritized recognition features such as peptide foreignness or agretopicity exhibited no benefit and sometimes reduced prediction accuracy. However, these attributes strengthened immunogenic peptide selection when combined with presentation features, suggesting a disconnect between peptide features …
Identification of neoantigens for individualized therapeutic cancer ...
WebFeb 12, 2024 · Calculation of differential agretopicity index for neoantigens Differential agretopicity index (DAI), which has been confirmed at a survival predictor in melanoma … WebFeb 10, 2024 · 10 To account for correlation among MHC binding affinity, MHC binding stability, and agretopicity 11 values, we fit a Gaussian copula. 12 Newly gained neoantigens were assigned values sampled from these distributions. We 13 discarded transcript abundance due to conflation with clonality and used the remaining four high temp marker pen
pVACtools: a computational toolkit to identify and visualize
WebI also assessed neoantigen quality metrics such as differential agretopicity, viral homology, and the novel metric of dissimilarity to the self-proteome to identify the most likely … WebOct 1, 2024 · The differential binding affinity of the neoantigens in comparison to wildtype was calculated as mean differential agretopicity index (DAI) = W T - M T. Patient survival was estimated by the Kaplan-Meier method. WebOct 9, 2024 · For immunogenicity, foreignness related to immunogenic tolerance and agretopicity were identified as parameters with the highest impact, since 50% of the elucidated immunogenic tumor epitopes in ... ez mart hooks