WebOct 31, 2013 · The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor-suppressing lipid phosphatase that is frequently absent in breast tumors. Thus, the stability of PTEN is essential for tumor prevention and therapy. The ubiquitin-proteasome pathway has an important role in regulating the functions of PTEN. Specifically, carboxyl … WebDec 20, 2013 · Overexpression of CHIP promoted degeneration of PTEN, which can increase the activation of PI3K pathway to promote the phosphorylation of FoxO3. FoxO3 binding to bim and pten promoters was ...
The Chaperone-assisted E3 Ligase C Terminus of Hsc70 …
WebJan 25, 2024 · ChIP analysis of the PTEN promoter revealed that Rsu1 depletion prevented binding of ATF2 to a positive regulatory site in the PTEN promoter and the enhanced binding of cJun to a negatively regulatory PTEN promoter site. These results demonstrate a mechanism by which Rsu1 adhesion signaling alters the balance between MKK4-p38 … WebJan 3, 2024 · CHIP was found to monoubiquitinate PTEN on K13 and K289 residues. Finally, we showed that CHIP-mediated monoubiquitination of PTEN resulted in … dick\u0027s sporting goods bowling balls
BAG5 regulates PTEN stability in MCF-7 cell line -BMB Reports
WebMay 1, 2024 · In human prostate cancer, PTEN is negatively correlated with CHIP in vitro and in vivo [120]. Lv et al. [121] demonstrated that CHIP decreases the protein level of … WebPTEN (phosphatase and tensin homologue deleted on chromosome ten), also referred to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers (1). PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase (2). WebJun 8, 2024 · Discussion. In contrast to a comprehensive understanding of PTEN regulation in cell lines, relatively little is known about modes of PTEN regulation in vivo.Although several ubiquitin ligases, including Nedd4-1, XIAP, WWP2 and CHIP, have been demonstrated to interact with and degrade PTEN in a variety of cell types in vitro, these … dick\u0027s sporting goods bowling bags