WebNov 8, 2024 · Q. Serum B12 <200 but normal homocysteine and normal MMA — is it just the early stages of B12 deficiency? Both homocysteine (Hcy) and methylmalonic acid (MMA a test may be used to help diagnose an early or mild vitamin B12 deficiency) depend on more factors than just B12, including more nutrients (eg. folate). ... High B12 may also be found ... WebApr 27, 2024 · Elevated MMA in the blood indicates insufficient B12. 2 Having results for both B12 and MMA is helpful, as a high MMA might indicate a mild deficiency or a developing deficiency if B12 results are on the lower end of the normal range. Favorable ranges B12: 160-950 pg/ml or 118-701 pmol/L MMA: Normal ranges vary somewhat …
High serum b12, high MMA and low tran... - Pernicious Anaemi...
WebDec 3, 2024 · Vitamin B12 (cobalamin) is an essential micronutrient that acts as a coenzyme in homocysteine and methylmalonic acid (MMA) metabolism ( 3, 4 ). Accumulated evidence has supported a biological link between cobalamin deficiency and diabetes that is partly explained by insulin resistance and oxidative stress ( 5 ). WebOct 18, 2024 · In a significant number of people high levels of B12 can cause a functional B12 deficiency (your body reacts to the high levels of B12 making the mechanism that allows B12 to get into your cells much less efficient so you are deficient at the cellular level though the levels in your blood are high. pope\u0027s cathedral
Active B12 assay for diagnosing vitamin B12 deficiency
WebFeb 12, 2024 · Transcobalamin is one of the two proteins that bind to B12 in the blood. It's also known as 'Active' B12 or holotranscobalamin. The bottom of the normal range is normally between around 20 and 35 pmol/L - nice.org.uk/advice/mib40/re... - although some labs quote a grey area up to 75 pmol/L. WebJul 20, 2024 · Such a high MMA means that you are just not getting enough B12 into cells. You should be aiming to increase supplementation significantly with whatever form (s) … pope\u0027s christmas eve mass 2021