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WebSep 29, 2024 · The most common side effects of metformin include. stomach discomfort, upset stomach, diarrhea, and. decreased appetite. These side effects usually are mild and tend to decrease in severity over time despite continuation of treatment. Other reported side effects of metformin include. metallic taste, interference with vitamin B12 absorption, and. WebDrugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 2 Apr 2024), Cerner … Web- Combination therapy with other oral hypoglycemics, insulin, etc. • Factors influencing bioavailability (food, drugs, first pass) • Key disposition factors (protein binding in sulfonylureas) • Relative onset of action and relationship to mechanism or other factors • Relative duration of action and factors that influence duration of action ravine\u0027s pt