Son of sevenless homolog 1 sos1
WebSon of sevenless homolog 1. Gene. SOS1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 1333. Protein existence. Evidence at … WebDec 2, 2024 · SOS1, son of sevenless homolog 1: The guanine nucleotide exchange factor is the protein encoded by this gene. RAS proteins are membrane proteins that interact with guanine nucleotides and engage in signaling cascades. Gingival fibromatosis type 1 and Noonan syndrome type 4 are related to mutations in this gene [42].
Son of sevenless homolog 1 sos1
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WebSon of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents a unique opportunity for treating RAS-addicted … WebSOS1 son of sevenless homolog 1 (Drosophila) ... SOS1, GINGF, NS4, SOS-1, Son of sevenless homolog 1, GF1, GGF1: Target Sequences: NM_005633 NP_005624.2 Q07889: Publications (1) 1. Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer.
WebSon of sevenless homolog 1 (SOS1) is a crucial regulator of KRAS to modulate KRAS from inactive to active states. We previously discovered tetra-cyclic quinazolines as an … WebSon of sevenless homolog 1 (SOS1), a member of the SOS family, is a cohesion protein that plays an important role in the intracellular signal transduction pathways [Citation 15]. …
WebSon of sevenless homolog 1. Gene. Sos1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Mus musculus (Mouse) Amino acids. 1319. Protein existence. Evidence at … WebSon of sevenless homolog 1 (SOS1) is a crucial regulator of KRAS to modulate KRAS from inactive to active states. We previously discovered tetra-cyclic quinazolines as an improved scaffold for inhibiting SOS1-KRAS interaction. In this work, we report the design of tetra-cyclic phthalazine derivatives for selectively inhibiting SOS1 against EGFR.
WebOrthologous to several human genes including SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2024] sos-1 Son of sevenless homolog [] Gene ID: 178846, updated on 12-Aug-2024. Summary. Enables calmodulin ... Son of sevenless homolog.
WebSon of sevenless homolog 1 (1333 aa, ~152 kDa) is encoded by the human SOS1 gene. This protein is involved in the mediation of guanine nucleotide exchange for RAS superfamily … hilgardstraße speyerWebSOS1. Official Full Name. son of sevenless homolog 1 (Drosophila) Background. This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. smart 2 wayWebGTPase HRasSon of sevenless homolog 110-[(4-fluorophenyl)methyl]-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoleMAGNESIUM IONPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER. NCBI. National Center for Biotechnology Information. Search. ... SON of Sevenless Homolog 1 (Gene symbol: SOS1) Chemicals and Non-standard … hilgardstraße 9 speyerWebFeb 23, 2024 · SOS1 INHIBITORS. Abstract. The present invention relates to compounds that inhibit Son of sevenless homolog 1 (SOS1) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present … hilgarth architekt marktredwitzWebson of sevenless homolog 1; son of sevenless homolog 1 (Drosophila) SOS1_HUMAN; Additional Information & Resources. Tests Listed in the Genetic ... Sotillo M, Rodriguez … hilgardstraße 30 67346 speyersmart 2014 fortwoWebSon of sevenless homolog 1 (SOS1) is a gene that encodes a protein that functions as a guanine nucleotide exchange factor for Ras proteins. The protein regulates RAS proteins … hilgarth asphalt